One approach is to find tumour - associated and microenvironment - associated oncoantigens required for progression from one tumour stage to the next by comparing gene signatures isolated from the different stages of tumour progression in cancer - prone transgenic mice 一种方法就是去寻找肿瘤相关及微环境相关的癌基因，而这些癌基因则是通过比较患瘤倾向的转基因小鼠的肿瘤进展不同阶段分离出来的基因信号而来发现从肿瘤发展的一个阶段到下一个阶段所必需的基因。
